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Hypophosphatasia (HPP)
EHR toolkit

A disease too important to miss

  • Rare diseases, like HPP, pose unique challenges in the recognition of affected patients. As a result, critical diagnoses can be delayed or missed1,2
  • DeciphEHR provides educational resources to help health systems, hospitals, and specialty practices leverage their electronic health record (EHR) systems to help triage suspect patients for further clinician evaluation and employ diagnostic best practices

Take action with an HPP toolkit.

Leveraging EHRs may help health organizations triage patients for further evaluation3,4

Thumbnail image of the Disease Overview

HPP Overview
Thumbnail image of the Implementation Guide

HPP Implementation Guide

Click to review additional resources

Circular icon with arrow | Click to review additional resources
Download Now button: HPP Code List (excel)

HPP Code List (excel)
Download Now button: Leveraging EHRs

Leveraging EHRs may help health systems triage HPP patients for further evaluation
Download Now button: Adult with HPP Clinical Criteria Checklist

Adult with HPP Clinical Criteria Checklist

designed to assist HCPs with triaging patients suspected of having HPP for further evaluation
Download Now button: Pediatric and Perinatal Patient with HPP Clinical Criteria Checklist

Pediatric and Perinatal Patient with HPP Clinical Criteria Checklist

designed to assist HCPs with triaging patients suspected of having HPP for further evaluation

Why is HPP patient recognition so important?

Heart Being Monitored icon: HPP

HPP is a serious condition that may lead to death in infants or young children or severe physical impairment at any age.2,5

Patient icon: HPP

HPP can present at any age, causing varying degrees of impairment.2

A radial representing the prevalence of HPP icon

The birth prevalence of severe HPP has been estimated at 1 in 300,000.6

References: 1. Navarrete-Opazo AA, Singh M, Tisdale A, Cutillo CM, Garrison SR. Can you hear us now? The impact of health-care utilization by rare disease patients in the United States. Genet Med. 2021;23(11):2194-2201. 2. Högler W, Langman C, da Silva HG, et al. Diagnostic delay is common among patients with hypophosphatasia: initial findings from a longitudinal, prospective, global registry. BMC Musculoskelet Disord. 2019;20(1):80. 3. Ben-Assuli O, Sagi D, Leshno M, Ironi A, Ziv A. Improving diagnostic accuracy using EHR in emergency departments: a simulation-based study. J Biomed Inform. 2015;55:31-40. 4. Quinn HB, Busch RS, Kane MP. The occurrence and burden of hypophosphatasia in an ambulatory care endocrinology practice. Endocr Pract. 2021;27(12):1189-1192. 5. Whyte MP, Leung E, Wilcox WR, et al. Natural history of perinatal and infantile hypophosphatasia: a retrospective study. J Pediatr. 2019;209:116-124.e4. 6. Mornet E, Yvard A, Taillandier A, Fauvert D, Simon-Bouy B. A molecular-based estimation of the prevalence of hypophosphatasia in the European population. Ann Hum Genet. 2011;75(3):439-445.